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A registry-based review identified 224 eligible clinical trials worldwide, with a steady increase in research focused primarily on knee osteoarthritis

2026 Regulatory Update: On April 15, 2026 the FDA removed both BPC-157 and TB-500 from its Category 2 restricted list

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Reported concerns may include headache, nausea, injection-site irritation, fatigue, or unpredictable responses depending on product quality and route of administration